2/15/2023 0 Comments Critical ops mod 0.9 11 f172Reducing the plasma concentration of a specific antigen use of the Uptake into cells use of the antigen-binding molecules for Molecules for improving antigen-binding molecule-mediated antigen Pre-existing anti-drug antibody use of the antigen-binding Without an increased binding activity at neutral pH for a Having an increased FcRn-binding activity at neutral or acidic pH Neutral pH an antigen-binding molecule comprising saidįcRn-binding domain, which has low immunogenicity, high stabilityĪnd form only a few aggregates a modified antigen-binding molecule Having an enhanced affinity for the Fc Receptor neonatal (FcRn) at The present invention provides: a modified FcRn-binding domain THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN Invention is credited to Tomoyuki Igawa, Taichi Kuramochi, Atsuhiko Maeda, Futa Mimoto. The applicant listed for this patent is Chugai Seiyaku Kabushiki Kaisha. This patent application is currently assigned to Chugai Seiyaku Kabushiki Kaisha. patent application number 14/347187 was filed with the patent office on for therapeutic antigen-binding molecule with a fcrn-binding domain that promotes antigen clearance.
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